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Pepin’s Pharmaceutical Prattle for 02-21-2005

 

 

Quote of the day:  

A misery is not to be measure from the nature of the evil, but from the temper of the sufferer. Joseph Addison (1672 - 1719)

 

Good morning!

 Good morning ! 

How to Boil a Frog

 Before you call the ASPCA (http://www.aspca.org/site/PageServer) , please read this through. No frogs will be harmed in this Prattle and we will use only recycled electrons. Happy?

 Cold blooded animals experience temperature differently than warm blooded creatures.  Each will detect rapid changes in temperatures and will move away from the noxious stimulus. .  A frog, for instance, would not take warmly to being dropped into hot water if previously at room temperature. However, if you put the frog into room temperature water and SLOWLY started to heat the water, the frog would not detect the temperature difference until it was too late.

The warm blooded animals have their own “thermostat” to compare to the external temperature. Too hot or too cold and homeostatic mechanisms kick in (sweating, panting, shivering, etc).  Cold blooded animals don’t appear to notice.

“So, old weird bald one, what does this have to do with drugs?” you might say. Consider the members of employer or state sponsored pharmaceutical benefit plans as frogs. Some are already in hot water relative to their prescription drug benefits. Their employer (plan sponsor) has already instituted mandatory generic, prior authorizations, restrictive networks, and Spartan formularies. Will they rebel if a mandatory mail order is instituted for maintenance drugs or another drug is subject to quantity limits? They probably will not like the change but won’t quit.

Take another group of frogs...those members who are at “room temperature” (two tier- open formulary with no limits on quantity or any prior authorization). How would they react to the aggressive plan mentioned above? They would likely “scream bloody murder” when hit with such a drastic change!

So how do you get those comfortable frogs (members) to a pharmaceutical benefit plan that employers/spnsors can afford?  In other words “how do you boil a frog?”   The technique is the same as in the wild kingdom…you turn up the heat slowly. You might start with a 3 tier benefit that asks members to pay more for the more expensive drugs. Next you could add a provision where the member pays the difference between generic drugs and brand drugs if they choose to use the brand. Prior authorizations for more drugs can be added (as they make sense) to assure the clinically and fiscally responsible use of drugs. Increased flat copays or coinsurance every year might at least keep pace with inflation.  Limiting the network could shave some costs without inciting a riot. There are many tools that can be used to benefit the plan sponsors and the members. Just don’t put them all in at once.  That said, you HAVE TO START using some of them or the plan sponsors will be the ones in hot water along with their shareholders/stakeholders/taxpayers.

Medicare recipients (metaphorically the ‘old frogs’) are “already in hot water” because they have been paying full price for their medications. If the new Medicare Part D program does not institute PBM practices to manage the costs from the very start then those old frogs will find themselves in comfortably cool water and much more resistant to effective management in the future. I am not proposing to be mean but to be prudent. As a country we can not afford to turn down the heat too much or the entitlement mentality will only expand.

With pharmaceutical expenses rising, inaction is a negative action. Start now to use effective tools but prepare to hear some croaking. It may be the only way to preserve the pond.

 Steve

     -----

ps. Best answer this week to the question "How are you?" was "Fantastic and getting better!

 

1) Vioxx the new Phoenix?

The FDA expert panel concluded three days of deliberation and hearings on the COX II inhibitors last Friday. It appears that Vioxx 12.5 mg and 25 mg strengths may go back on the market. This could happen very rapidly because Merck took the drug off voluntarily and would not have to go through a re-approval. The other two, Bextra and Celebrex, also received a stay of execution. The new COX II’s in clinical trials but not yet approved will likely regain momentum toward the market. After we all have a group hug over this one we should remember that the less expensive, generic NSAIDS work just as well and are generally no less safe that the COX IIs.

http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2005-02-19T004451Z_01_N18361548_RTRIDST_0_HEALTH-HEALTH-PAINKILLERS-DC.XML

 ( the Phoenix was the legendary bird that rose from the ashes)

2) What goes around….comes around…again!

Prior to penicillin, syphilis was considered a death warrant. Prior to anti-retrovirals, HIV was considered the same. Truth is…. both run wild, are becoming more resistant and will return to kill. New strain of HIV is drug resistant and rapidly progresses to AIDS.

http://www.pharmalive.com/news/index.cfm?articleID=212518&categoryid=9&newsletter=1

3) FDA approves an anti-shot shot.

About 1 in 1 million people vaccinated against small pox will have a bad reaction to the injection. This new FDA approved drug can be used in these rare cases. Don’t expect this to hit your top 1000 drugs any time soon…. or ever. Not necessarily useful news but not all Prattle is!

http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2005-02-18T225310Z_01_N18208566_RTRIDST_0_HEALTH-HEALTH-SMALLPOX-TREATMENT-DC.XML

or  http://www.fda.gov/bbs/topics/ANSWERS/2005/ANS01341.html

4) Kough Koncoction Kacks Kids

Promethazine (Phenergan) shown to cause fatal respiratory problems in some children less than 2 years old. Labeling was just revised but thought you might want to know if you had some in the medicine cabinet.

http://www.fda.gov/medwatch/SAFETY/2005/phenergan_deardoctorletter.pdf

 

            Call the Senior Lending Specialist I use: Maria (Pepin) Sifuentes       at 1-800-322-4025 Extn 724

 msifuentes@affinity-mortgage.com

Mention the Prattle and get $100 off your closing costs.

www.affinity-mortgage.com   

 5) Elidel and Protopic increase cancer risk?

Topical medicine used against eczema may trigger cancer. A lot of people have been exposed so this might be something to watch. Expect a minimum of a labeling change.

http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=7639083

 6) Tip of the tort?

It appears that tort reform has begun. New law passed by Congress to limit Class Action Suits to federal courts and limit the amount that lawyers may receive for their work. Should we consider this the first increase in heat toward boiling a lawyer?

http://startribune.com/stories/587/5246618.html

 7) FDA going to the dogs?

Well maybe not the dogs but quite possibly to the veterinarian. Lester Crawford is a veterinarian. He has been nominated to head the FDA (has been acting director for a year already and has overseen some pretty dicey issues). He has proven himself as an administrator who understands food and drugs. My dad thought that vets were probably smarter than physicians because they had to diagnose their patients without the patients using words to describe what was wrong. (I think he will do just fine). If you think he would make a good head of the FDA then paw the ground three times.   (Maybe he will understand the frog analogy)

http://www.bloomberg.com/apps/news?pid=10000103&sid=aNkwevvzQxoY&refer=INTERNET_DRUG_NEWS_INC

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  Have a SUPER-FANTASTIC week. Steve
  Disclaimer: "Pepin's Pharmaceutical Prattle" (AKA "The Prattle") is the property of PHARMWORKS, LLC and Steven M. Pepin, Pharm. D, BCPS. The opinions expressed are those of the bald-headed author. To start or stop any drug without the advice and supervision of your physician would be stupid. So don't do anything based upon what you read here without professional advice. To be added to or removed from the distribution list please e-mail your request to spepin@pharmworks.com . All insightful comments from readers are thoughtfully considered (the rest are callously discarded). Copyright 1998-2005 PHARMWORKS, LLC all rights reserved.

 

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